产品名称：	GC- 药典二氧化碳中碳氢化合物色谱测定
产品型号：	GC-
品牌：	1941
产品数量：
产品单价：	面议
日期:	2023-03-13

GC- 药典二氧化碳中碳氢化合物色谱测定的详细资料

药典二氧化碳中碳氢化合物色谱测定
药典二氧化碳中碳氢化合物色谱测定 详细信息：

二氧化碳EryanghuatanCarbon DioxideCO₂ 44.01
本品含CO₂不得少于99.5%(ml/ml)。
【性状】 本品为无色气体；无臭；水溶液显弱酸性反应。
本品1容在常压20℃时，能溶于水约1容中。
【鉴别】 (1)取本品，通入氢氧化钡试液中，即生成白色沉淀；沉淀能在醋酸中溶解并发生泡沸。
(2)本品能使火焰熄灭。
(3)本品的红外光吸收图谱应与对照的图谱(图1)一致(通则0402)。
【检查】 酸度 取水100ml，加甲基橙指示液0.2ml，混匀，分取各50ml，置甲、乙两支比色管中，于乙管中，加盐酸滴定液(0.01ml/L)1.0ml，摇匀；于甲管中，通入本品1000ml(速度为每小时4000ml)后，显出的红色不得较乙管深。
水分 取本品，通入露点分析仪测定，含水分不得过百万分之六十七。
—氯化碳 取本品，用一氧化碳检测管测定，含一氧化碳不得过百万分之五
二氧化硫 取本品，用二氧化硫检测管测定，含二氧化硫不得过百万分之二。
磷化氢 取本品，用磷化氢检测管测定，含磷化氢不得过千万分之三。
硫化氢 取本品，用硫化氢检测管测定，含硫化氢不得过百万分之一。
氨 取本品，用氨检测管测定，含氨不得过百万分之二十五。
碳氢化合物 取本品作为供试品气体，取甲烷含量为0.0020%的气体(以氮气为稀释剂)作为对照气体，照气相色谱法(通则0521)试验，用玻璃球为填料的色谱柱(4mm×0.8m，80目)；柱温为110℃；进样口温度为110℃；检测器为火焰离子化检测器，温度为120℃。量取供试品气体与对照气体，注入色谱仪，在净化温度为360℃时测得的峰面积为相应空白值；量取供试品气体与对照气体，注入色谱仪，测定峰面积，减去相应空白值后的峰面积为校正峰面积。按外标法以校正峰面积计算，含碳氢化合物(以甲烷计)不得过0.0020%。
【含量测定】 照氧项下的方法，除改用附图所示的吸收器，并以氢氧化钾溶液(1→2)125ml代替铜丝与氨-氯化铵溶液作为吸收液，并以酸化水(对甲基橙指示液显酸性)取代饱和氯化钠溶液注入平衡瓶J中外，依法操作，剩余的气体体积恒定为止。读取量气管内的液面刻度，算出供试品的含量，即得。

药典二氧化碳中碳氢化合物的测定，叙述粗略，许多制药企业很难操作，滕州市浩瀚色谱仪器技术服务有限公司，，，研发出药典CO2中碳氢化合物测定的详细的分析方案，欢迎咨询洽谈。

具体配置如下：

1.GC-7990气相色谱仪

2.氢火焰检测器FID

3.气体进样装置

4.标准气体：CH4/N2

5.填充柱：1m*1/8（安捷伦，岛津。热电及进口仪器用），0.8m*4mm，0.8*3mm（国产仪器用）

6.氢气发生器HHH-300

7.空气发生器：HHA-3L

8.氮气钢瓶及减压阀

9.电脑，打印机

10.核心部件：净化装置（浩瀚色谱研制，）

药典二氧化碳中碳氢化合物色谱测定 测试谱图：



Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide
Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide Details:

Carbon dioxide Eryanghuatan Carbon DioxideCO2 44.01
This product contains not less than 99.5% CO2 (ml/ml).
【Properties】 This product is a colorless gas; odorless; aqueous solution is weakly acidic.
This product 1 can be dissolved in water at about 1 °C at normal pressure.
[Identification] (1) Take this product and pass it into the barium hydroxide test solution to form a white precipitate; the precipitate can be dissolved in acetic acid and bubbled.
(2) This product can extinguish the flame.
(3) The infrared absorption spectrum of this product should be consistent with the control map (Figure 1) (General Rule 0402).
[Check] Take 100ml of acidity, add 0.2ml of methyl orange indicator solution, mix well, take 50ml each, separate two colorimetric tubes of armor and B, add hydrochloric acid titration solution (0.01ml/L) in the tube. 1.0ml, shake well; in the tube, after entering 1000ml of this product (speed is 4000ml per hour), the red color should not be deeper than the tube.
Moisture Take this product and measure it with a dew point analyzer. The moisture content should not exceed 67 parts per million.
- Chlorinated carbon Take this product and measure it with carbon monoxide detector tube. The carbon monoxide should not exceed 5 parts per million.
Sulfur Dioxide Take this product and measure it with sulfur dioxide detection tube. The sulfur dioxide should not exceed 2 parts per million.
Phosphine is taken from this product and measured with a phosphine detector tube. The phosphine containing hydrogen should not exceed 3 parts per million.
Hydrogen sulfide Take this product and measure it with hydrogen sulfide detection tube. The hydrogen sulfide content should not exceed one part per million.
Ammonia Take this product and measure it with ammonia test tube. The ammonia content should not exceed 25 parts per million.
Hydrocarbon is taken as the test gas, and a gas with a methane content of 0.0020% (with nitrogen as a diluent) is used as a control gas, and gas chromatography (General Rule 0521) is used to test the column with glass spheres as a filler ( 4mm × 0.8m, 80 mesh); column temperature is 110 ° C; inlet temperature is 110 ° C; detector is flame ionization detector, temperature is 120 ° C. The test gas and the control gas are measured and injected into the chromatograph. The peak area measured at the purification temperature of 360 ° C is the corresponding blank value; the gas for the test sample and the control gas are taken, injected into the chromatograph, and the peak area is measured and reduced. The peak area after the corresponding blank value is the corrected peak area. According to the external standard method, the hydrocarbon content (in terms of methane) should not exceed 0.0020%.
[Content determination] In the method of oxygen, except that the absorber shown in the figure is used, and 125ml of potassium hydroxide solution (1→2) is used instead of copper wire and ammonia-ammonium chloride solution as the absorption liquid, and The acidified water (acidic to the methyl orange indicator liquid) is replaced by a saturated sodium chloride solution into the balance bottle J, and operated according to the law until the remaining gas volume is constant. Read the liquid level scale in the trachea and calculate the content of the test sample.


The determination of hydrocarbons in the Pharmacopoeia carbon dioxide is crude and many pharmaceutical companies are difficult to operate. Tengzhou Haohao Chromatography Instrument Technology Service Co., Ltd. keeps pace with the times and develops the determination of hydrocarbons in the Pharmacopoeia CO2 under the guidance of the scientific development concept. Detailed analysis plan, welcome to consult and negotiate.
The specific configuration is as follows:
1.GC-7990 Gas Chromatograph
2. Hydrogen flame detector FID
3. Gas sampling device
4. Standard gas: CH4/N2
5. Packed column: 1m*1/8 (Agilent, Shimadzu. Used for thermoelectric and imported instruments), 0.8m*4mm, 0.8*3mm (for domestic instruments)
6. Hydrogen generator HHH-300
7. Air generator: HHA-3L
8. Nitrogen cylinder and pressure reducing valve
9. Computer, printer
10. Core components: purification device (the development of vast chromatography, domestic original)


Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide Test Spectra: